Earlier on Wednesday, Amanda Anisimova sailed past Siegemund as she returned to the grass for the first time since her heavy Wimbledon final defeat last year.
The American reached her first Grand Slam final at the All England Club last season, but suffered an excruciating 6-0 6-0 loss against Poland’s Iga Swiatek.
It was the first time a woman had won a Wimbledon final with a double bagel – the name given to a victory without dropping a game – since Dorothea Lambert Chambers in 1911.
But the 24-year-old, a finalist at Queen’s last year, showed why she is so effective on grass with a commanding 6-1 6-3 win over world number 44 Siegemund.
“It was an incredible year for me last year,” said Anisimova, who finished as runner-up to Aryna Sabalenka at the 2025 US Open.
“A lot of highs, a lot of low moments where there were some tough lessons I had to learn but those are the ones that shaped me as a person and a athlete.
“I’m trying to carry that into this year – everything that I learned.”
The second seed, who received a first-round bye, will face fellow American Iva Jovic in the quarter-finals.
The 18-year-old sixth seed defeated her good friend Alexandra Eala, 21, for the second time in two weeks with a 6-2 6-2 victory on Andy Murray Arena.
“There is no bad blood. We were just talking in the locker room. It’s all good. We’re back to being friends now off the court,” said Jovic, who also beat Eala in the first round of the French Open.